Pregnyl Chorionic Gonadotropin for Injection: Side Effects, Uses, Dosage, Interactions, Warnings

Pregnyl Chorionic Gonadotropin for Injection: Side Effects, Uses, Dosage, Interactions, Warnings

Ovarian Hyperstimulation Syndrome (OHSS) is a medical event distinct from uncomplicated ovarian enlargement and may progress rapidly to become a serious medical event. OHSS is characterized by a dramatic increase in vascular permeability, which can result in a rapid accumulation of fluid in the peritoneal cavity, thorax, and potentially, the pericardium. The early warning signs of the development of OHSS are severe pelvic pain, nausea, vomiting, and weight gain.

In women with recognized risk factors, the benefits of ovulation induction, in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment need to be weighed against the risks. Pregnancy itself also carries an increased risk of thrombosis. Side effects for Pregnyl 500 can range from mildly uncomfortable to life threatening. Many patients may experience common side effects such as restlessness, headache, irritability, fatigue, breast swelling or tenderness, or water weight gain.

  • Tell your doctor about all the prescription and over-the-counter medications and supplements you use.
  • If there is evidence that OHSS may be developing prior to hCG administration, withhold hCG.
  • Pregnancy itself also carries an increased risk of thrombosis.
  • In most instances, treatment of women with FSH results only in follicular recruitment and development.

Inform your doctor about any other medications you are taking to ensure the use of IU Injection is safe for you. It includes over-the-counter drugs, herbal remedies, vitamins and other dietary supplements. The dose of injection you receive would depend upon your gender and the condition being treated as per the prescription of your doctor. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 3 Mar 2024), Cerner Multum™ (updated 17 Mar 2024), ASHP (updated 20 Mar 2024) and others.

What are the uses of Pregnyl 5000 IU Injection

Human chorionic gonadotropin (HCG) is given as an injection under the skin or into a muscle. If you use this medicine at home, your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Do not use the medication if it has changed colors or the liquid has any particles in it. Pregnyl® (chorionic gonadotropin for injection USP) is a highly purified pyrogen-free preparation…

Clinical studies of PREGNYL (chorionic gonadotropin) for injection did not include subjects aged 65 and over. There have been infrequent reports of ovarian neoplasms, both benign and malignant, in women who have undergone multiple drug therapy for ovarian stimulation; however, a causal relationship has not been established. Infertile women undergoing Assisted Reproductive Technologies (ART) have an increased incidence of ectopic pregnancy.


It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised if hCG is administered to a nursing woman. The risk of spontaneous abortion (miscarriage) is increased with gonadotropin products. The increased risk may be a factor of the underlying infertility. If serious OHSS occurs, stop gonadotropins, including hCG, and consider whether the woman should be hospitalized. Treatment is primarily symptomatic and overall consists of bed rest, fluid and electrolyte management, and analgesics (if needed).

Abdominal pain, abdominal distension, gastrointestinal symptoms including nausea, vomiting and diarrhea, severe ovarian enlargement, weight gain, dyspnea, and oliguria have been reported with OHSS. Clinical evaluation may reveal hypovolemia, hemoconcentration, electrolyte imbalances, ascites, hemoperitoneum, pleural effusions, hydrothorax, acute pulmonary distress, and thromboembolic reactions. Transient liver function test abnormalities suggestive of hepatic dysfunction with or without morphologic changes on liver biopsy, have been reported in association with OHSS. OHSS occurs after gonadotropin treatment has been discontinued and it can develop rapidly, reaching its maximum about seven to ten days following treatment. Usually, OHSS resolves spontaneously with the onset of menses. Safe and effective induction of ovulation with use of PREGNYL requires monitoring of ovarian response with serum estradiol and transvaginal ultrasound on a regular basis.

A few side effects of using Pregnyl 5000 IU Injection is severe pelvic pain, swelling of hands and legs, abdominal pain, shortness of breath, weight gain, diarrhoea, nausea or vomiting and urinating less than normal. Less serious side effects include headache, feeling restless and irritable, water weight gain, depression, breast swelling, and mild pain on site of injection. Pregnyl for men is used to treat conditions such as delayed puberty, oligospermia (Low sperm count), and undescended testes. Male patients will be administered 2 to 3 times a week over the course of weeks or months depending on what problem requires Pregnyl.

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Michael Picco

Michael Picco

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